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Choose collection locationLiver Function · Individual laboratory test
Globulins include antibodies and other proteins carried in blood. The total globulin result groups many different proteins into one figure.
Clinical authorDr Nirupama SabhapathySpecialist Clinical Pathology
Understanding the test
Also called Immune Protein (Globulin)
A globulin measurement helps explain an unexpected total protein or albumin-to-globulin balance. Some components reflect immune activity and others have different roles.
The globulin fraction includes several protein families involved in immunity and transport.
Albumin, total protein and, if indicated, electrophoresis may help explain an abnormal result.
Before your sample
No fasting is generally needed. Maintain your usual fluid intake and tell the clinician about recent illness or treatment with antibodies or other blood products.
A clinician takes a small sample of blood from a vein. The laboratory uses serum, the liquid separated from the blood after it clots.
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24 hoursLaboratory turnaround
An abnormal globulin value does not identify one specific protein. Where necessary, the clinician may request a test that separates the protein groups.
From sample to follow-up

Choose your location, add the test to your care bag and select a time. If you are booking for someone else, assign the test to them in checkout.
Choose collection locationLook for Globulin in your report. Use the sample type and collection time when comparing it with an earlier report.
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Ask whether a change in total protein is explained by albumin, globulins or both, and whether more specific protein testing would help.
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Patient questions
No. The albumin level and other protein tests can help narrow the explanation when the result is persistently unusual.
Albumin is a single protein, while globulin is the name for every other blood protein, including antibodies and transport proteins. Both come from the same blood sample: the laboratory measures total protein and albumin, and globulin is the difference. Reading them side by side helps your doctor tell whether a change comes from immune activity, liver disease or protein loss.
A low globulin suggests the body is making fewer antibodies, whether from an inherited condition or from immune-suppressing treatment, or that protein is being lost through the kidneys, as in nephrotic syndrome, or through the gut. Malnutrition, malabsorption and large volumes of intravenous fluid can also lower it. It matters most when infections keep recurring or swelling is unexplained.
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Written by Dr Nirupama Sabhapathy, Specialist Clinical Pathology. Medically reviewed by Dr Joyce Jose, Specialist Clinical Pathology, on .
Catalogue information and AED price checked on 2 November 2026. Clinical suitability, preparation, collection arrangements and turnaround are confirmed for your selected test.