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Choose collection locationBiochemistry · Individual laboratory test
Chloride is an electrolyte that helps maintain fluid and acid–base balance. Its relationship with sodium and bicarbonate is often the reason for the test.
Clinical authorDr Nirupama SabhapathySpecialist Clinical Pathology
Understanding the test
Also called Blood Chloride Electrolyte
Fluid loss, kidney disease and some medicines can alter chloride. A clinician may order it as part of an electrolyte assessment after vomiting or diarrhoea.
Chloride may change with sodium and water after significant fluid loss.
Chloride and bicarbonate can move in relation to one another when acid–base balance is disturbed.
Before your sample
Drink as you normally would unless you have a prescribed fluid restriction. Tell the team about recent vomiting, heavy fluid losses, diuretics or intravenous fluids. Chloride alone needs no fast.
A clinician takes a small sample of blood from a vein. The laboratory uses serum, the liquid separated from the blood after it clots.
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Chloride is usually read with sodium and bicarbonate. A pattern across these markers helps distinguish water-balance changes from acid–base disturbances.
From sample to follow-up

Choose your location, add the test to your care bag and select a time. If you are booking for someone else, assign the test to them in checkout.
Choose collection locationLook for Chloride in your report. Use the sample type and collection time when comparing it with an earlier report.
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Describe recent diarrhoea, vomiting or fluid treatment and ask how chloride fits with bicarbonate and sodium.
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Patient questions
Recent vomiting, diarrhoea, fluid treatment and certain medicines can affect the balance. The accompanying sodium, potassium and bicarbonate results supply context.
Sweating loses both water and salts. How chloride changes depends partly on what you have lost and replaced. Tell the clinician about heavy sweating or other fluid loss, and continue any fluid plan you have been prescribed.
Yes. Diuretics increase chloride loss through the kidneys and are one of the commonest reasons for a low result, and other blood pressure medicines, steroids and laxatives can also shift the electrolyte pattern. Tell the collection team what you take so the result is read in context; your doctor decides whether any change is needed, not the test alone.
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Written by Dr Nirupama Sabhapathy, Specialist Clinical Pathology. Medically reviewed by Dr Joyce Jose, Specialist Clinical Pathology, on .
Catalogue information and AED price checked on 2 November 2026. Clinical suitability, preparation, collection arrangements and turnaround are confirmed for your selected test.