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Choose collection locationTumour Markers · Individual laboratory test
AFP is a protein that can be measured in selected liver and germ-cell conditions. Pregnancy and non-cancerous liver disease can also influence it.
Clinical authorDr Nirupama SabhapathySpecialist Clinical Pathology
Understanding the test
Also called Liver & Germ-Cell Marker
A specialist may request AFP in defined liver surveillance or germ-cell tumour follow-up. The significance depends strongly on why it was ordered and whether pregnancy is relevant.
A specialist may use AFP alongside imaging and other findings in specific liver or germ-cell conditions.
A person's prior measurements help the specialist assess whether a change needs investigation.
Before your sample
Fasting is unnecessary. For monitoring, follow the specialist's timing and bring prior AFP values. Mention pregnancy, liver conditions and recent treatment.
A clinician takes a small sample of blood from a vein. The laboratory uses serum, the liquid separated from the blood after it clots.
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The direction of change is useful in a monitoring plan. Non-cancerous liver injury can raise AFP, and some tumours do not release it.
From sample to follow-up

Choose your location, add the test to your care bag and select a time. If you are booking for someone else, assign the test to them in checkout.
Choose collection locationLook for Alpha Fetoprotein (AFP) in your report. Use the sample type and collection time when comparing it with an earlier report.
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Review AFP with prior levels, liver findings and the specialist's intended monitoring interval.
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Patient questions
No. A normal result cannot exclude cancer and an elevated result has several explanations. Clinicians use it for defined indications with imaging or other follow-up.
AFP is made mainly by the fetal liver, so it rises normally in the mother's blood during pregnancy. A raised result in a pregnant woman is expected and is interpreted against completely different pregnancy criteria, not the adult range. Tell the team before the test if you are or might be pregnant, so the result is not read as abnormal.
Different assay methods produce AFP values that are not directly comparable, so a change between two laboratories may reflect the method rather than your health. If you are being monitored, give samples at consistent intervals and, where practical, through the same laboratory. Bring your previous AFP results so the direction of travel can be seen.
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Written by Dr Nirupama Sabhapathy, Specialist Clinical Pathology. Medically reviewed by Dr Joyce Jose, Specialist Clinical Pathology, on .
Catalogue information and AED price checked on 2 November 2026. Clinical suitability, preparation, collection arrangements and turnaround are confirmed for your selected test.