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Choose collection locationEndocrinology · Individual laboratory test
Anti-TPO measures antibodies to an enzyme used to make thyroid hormones. It may support an investigation of autoimmune thyroid disease.
Clinical authorDr Nirupama SabhapathySpecialist Clinical Pathology
Understanding the test
Also called Thyroid Autoantibody (Anti-TPO)
A clinician may measure anti-TPO to help explain a change in thyroid function or assess whether an autoimmune process is likely.
This antibody can support an autoimmune explanation for an abnormal thyroid function test.
If antibodies are present, a clinician may track TSH over time to see whether the gland's output changes.
Before your sample
Anti-TPO alone requires no fast. Give the team your thyroid treatment and biotin supplement details, particularly when thyroid hormone measurements share the draw.
A clinician takes a small sample of blood from a vein. The laboratory uses serum, the liquid separated from the blood after it clots.
Smart Report
24 hoursLaboratory turnaround
Antibodies can persist even when thyroid hormone levels change. Tracking symptoms, TSH and free T4 usually answers a different question from repeating an antibody measurement.
From sample to follow-up

Choose your location, add the test to your care bag and select a time. If you are booking for someone else, assign the test to them in checkout.
Choose collection locationLook for Anti-Thyroid Peroxidase Antibody (Anti-TPO) in your report. Use the sample type and collection time when comparing it with an earlier report.
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Review TSH and free T4 alongside anti-TPO to distinguish an antibody finding from a change in current thyroid function.
Patient questions
It can identify an autoimmune tendency even when thyroid hormone levels are currently normal. TSH and free T4 help determine current function.
TSH shows how well the thyroid is working right now; anti-TPO shows whether the immune system is targeting the gland. A positive anti-TPO with a borderline TSH raises the chance that thyroid function will drift over the years, so follow-up is usually closer. Treatment and dosing are guided by TSH and free hormones, never by the antibody level.
Thyroid demand rises during pregnancy, and a gland already under immune attack is less able to meet it. Knowing your antibody status beforehand lets your doctor monitor thyroid function more closely through pregnancy and the months after delivery.
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Written by Dr Nirupama Sabhapathy, Specialist Clinical Pathology. Medically reviewed by Dr Joyce Jose, Specialist Clinical Pathology, on .
Catalogue information and AED price checked on 2 November 2026. Clinical suitability, preparation, collection arrangements and turnaround are confirmed for your selected test.