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Choose collection locationDiabetes · Individual laboratory test
HOMA-IR uses fasting insulin and glucose together to estimate insulin resistance. It is a calculated index and should be interpreted in the clinical context.
Clinical authorDr Nirupama SabhapathySpecialist Clinical Pathology
Understanding the test
Also called Insulin Resistance Index
A clinician may use the index as supporting information when investigating metabolic changes. It requires glucose and insulin obtained together under fasting conditions.
The calculation draws on a paired fasting glucose and insulin measurement.
Looking at the two underlying results can explain why the index changed.
Before your sample
An overnight fast of eight to twelve hours is needed so glucose and insulin reflect the same baseline. Ask the prescribing clinician how to manage medicines during the fast.
A clinician takes a small sample of blood from a vein. The laboratory uses serum, the liquid separated from the blood after it clots.
Smart Report
24 hoursLaboratory turnaround
The result is an estimate based on a model. Insulin methods and population differences limit direct comparison between laboratories and make a universal cutoff inappropriate.
From sample to follow-up

Choose your location, add the test to your care bag and select a time. If you are booking for someone else, assign the test to them in checkout.
Choose collection locationLook for HOMA-IR: Insulin Resistance Index in your report. Use the sample type and collection time when comparing it with an earlier report.
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Ask to see the fasting glucose and insulin values behind the calculation and discuss how the index fits your wider metabolic assessment.
Patient questions
No. There is no single universal HOMA-IR cutoff for everyone. Clinicians use established glucose or HbA1c criteria when assessing diabetes.
Your pancreas may make more insulin to keep glucose in range. The index estimates that relationship from one fasting sample. It cannot tell if or when you will develop diabetes. For that question, your clinician considers your history and established glucose tests.
Routine PCOS care does not require HOMA-IR. If you and your clinician want to check how your body handles glucose, the international guideline identifies the 75 g oral glucose tolerance test as the most accurate option for people with PCOS.
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Written by Dr Nirupama Sabhapathy, Specialist Clinical Pathology. Medically reviewed by Dr Joyce Jose, Specialist Clinical Pathology, on .
Catalogue information and AED price checked on 2 November 2026. Clinical suitability, preparation, collection arrangements and turnaround are confirmed for your selected test.